Role of herbal compounds to treat Drug-Induced Liver Injury (DILI)
Role of herbal compounds to treat Drug-Induced Liver Injury (DILI)
- Author(s) A. Mannan, B. Pentela, D. Pathak and S. Das
- Year: 2025
- Month: January
- Volume: 64
- Pages: 47-58
The liver produces hormones, plasma proteins, aids in detoxification, breaks down red blood cells, and regulates the body's glycogen storage. Liver diseases and its after effects causes illness and death. Drug-induced liver injury (DILI) is a major clinical problem, which leads to substantial morbidity and mortality. Although DILI is uncommon but it occurs in hospitalised individuals with undetected liver problems. Different drugs are used in drug-induced liver injury in Eastern and Western nations. In Western regions, antibiotics are used to treat DILI, but in East, traditional Chinese medicine are used. Due to the limited effectiveness of traditional pharmacotherapies for liver injury, research is being conducted into alternate treatment methods. Herbal medications are widely used and are popular. We identified many plant chemicals (silymarin, curcumin, andrographolide, hesperidin, naringin, glycyrrhetinic acid, hawthorn extract, and epigallocathechin-3-gallate) with hepatoprotective properties. These substances have anti-inflammatory, anti-fibrotic and antioxidant properties. Additionally, herbal components alter drug metabolic pathways, to lessen the hepatotoxicity of pharmaceutical treatments. We address various drug-induced liver damage pathways and natural remedies for hepatotoxicity and also emphasized the significance of molecular mechanisms behind DILI and the reasons for choice of treatment drugs.
