Hepatotoxicity, which arises from exposure to various toxins, pharmaceuticals, infections, or metabolic disorders, is a significant global health issue. Traditional treatment methods often come with considerable side effects, leading to increased interest in plant-based solutions recognized for their effectiveness and safety. Historically, medicinal plants have been used in traditional medicine systems for liver protection, providing bioactive compounds such as flavonoids, alkaloids and polyphenols that demonstrate anti-inflammatory, antioxidant, and hepatoprotective effects. This review aimed to show the potential of different plants by examining their phytochemical compositions and mechanisms through which they mitigate liver damage and additionally, it provides a list of potential plant species for liver health applications. By analysing scientifically validated research and identifying less-studied plant species, this study underscores the necessity for further exploration to incorporate these natural remedies into contemporary therapeutic practices. Such an approach could facilitate the creation of innovative and sustainable treatments for liver-related conditions.