Guava (Psidium guajava L.) contains various biologically active compounds, such as kaempferol and quercetin, which possess anti-cancer properties. Its leaf has high concentration of polyphenols, flavones and tannins, while exhibiting lower levels of alkaloids, flavonoids, saponins and triterpenes. Despite the potent antibacterial properties of polyphenols, it may be inferred that the antimicrobial efficacy of guava is primarily attributed to its elevated levels of phenols, tannins, and flavonoids. Numerous research has demonstrated that guava leaf extracts have antibacterial properties in rats and guinea pigs, indicating that guava leaves and their other components may be utilized to treat many ailments, including diarrhea, spasms, rheumatism and wounds. This review elucidates the several phytochemicals found in Psidium guajava that are responsible for diverse biological activities. This work concentrates on the investigation of several bioactives that may be examined in future research to provide more beneficial outcomes.