Herbal medications and target-based drug delivery strategies for hypertension
Herbal medications and target-based drug delivery strategies for hypertension
- Author(s) Km. Shivangi, Rupa Mazumder, Swarupanjali Padhi and Manu Sharma
- Year: 2025
- Month: November
- Volume: 66
- Pages: 203-212
Heart failure, myocardial infarction, and stroke are among the major cardiovascular problems that can arise from high blood pressure, which is a common non-communicable condition. Beyond traditional medications, new herbal treatment techniques seek to treat hypertension by focusing on blood vessel smooth muscle function, inflammatory routes and pathways in the central nervous system. Novel approaches are intended to treat resistant hypertension, enhance blood pressure management, and accomplish further risk reduction beyond blood pressure reduction. Novel targets for antihypertensive treatment are also expected to be connected to RAAS. This review aimed to provide an in-depth mechanistic analysis of the intriguing new targets and the pharmacological action of phytochemicals associated with hypertension. These phytochemicals (Allicin, S-allyl cysteine) from Allium sativum L. (Garlic) and terpinen-4-ol from Alpinia zerumbet Pers. (Shell ginger), showed anti-hypertensive action, increasing NO activity. The other, crocin from Crocus sativus L. (Carl Linnaeus) (Saffron crocus), EGCG from Camellia sinensis (L.) (Tea plant), reduced oxidative stress by its antihypertensive action.
