Majority of cash crops have the problem of continuous cropping in the planting process, especially the genus Panax. A series of diseases occur in the process of ginseng planting, which will aggravate the obstacle of continuous cropping, directly lead to the significant decline of ginseng yield and quality, and seriously affect the development of ginseng planting industry. Taking two main species of Panax plants, namely Panax ginseng C. A. Mey and Panax notoginseng (Burkill)F.H. Chen ex C.H., this paper explains the three main factors affecting their continuous cropping, namely (i). Allelopathic autotoxic substances, (ii). Soil microbial community and (iii). Soil physico-chemical properties. The main methods to overcome continuous cropping obstacles were listed, including (i). Biological breeding, (ii). Soil sterilization, (iii). Establishment of reasonable farming system, (iv). Use of microbial fertilizer and (v). The directions of future research were discussed to provide scientific reference for the cultivation and management of alleviating or overcoming the obstacle of continuous cropping of ginseng.