Antioxidant and hepatoprotective potentiality of Trapa natans L. leaf extract in liver damage
Antioxidant and hepatoprotective potentiality of Trapa natans L. leaf extract in liver damage
- Author(s) Chandana Majee, Rupa Mazumder and Alka N. Choudhary
- Year: 2023
- Month: November
- Volume: 60
- Pages: 201-208
The antioxidant and hepatoprotective potentialities of the methanolic extract of Trapa natans L were investigated in this study. The DPPH, H2O2, and phosphomolybdate test methods were used to assess antioxidant activity. The paracetamol-induced hepatotoxic model in rats was used to investigate the hepatoprotective potentiality. The level of liver biochemicals such as ALT, AST, bilirubin, and total protein was examined to determine hepatoprotective potential. The Trapa natans L. (T.N) extract in different dose (200 & 400. mg/kg) were induced once a day orally. Serum enzymes like AST, ALT, ALP, and total bilirubin were detected for the animal treated in the test drug (T.N extract). Silymarin, a widely used drug used for liver damage that significantly protects the liver from damage caused by paracetamol, has been used. The histological analysis of rat liver reinforces the biochemical investigation. From the in-vitro and in-vivo antioxidant study, it was concluded that the plant extract has a potent free radical scavenging capacity. This investigation conclusively demonstrated that the Trapa natans L. plant extract has an excellent hepatoprotective effect in paracetamol-induced hepatotoxic rats. The free radical inhibition potentiality of polyphenolic chemicals found in the plant extract could be the mechanism of action of Trapa natans L.
